INS and Insulin resistance: Interestingly, the ROC analysis, which was used to determine the cut-off values for each of the variables defining cluster 1, revealed that individuals with high insulin secretion (HOMA2-B ≥83.8), moderate-to-high BMI (≥21.72), and high insulin resistance (HOMA2-IR ≥1.3831) can be allocated to cluster 1.