On the contrary, other potential prognostic factors such as histopathological grade, gender, age, primary tumor size, Ki-67, cardiac surgery, stable disease due to peptide-receptor radionuclide therapy (PRRT), SSA use, coexistence of tricuspid regurgitation with pulmonary regurgitation and presence of bone metastasis were not significantly associated to OS. This evidence concerns the gene MKI67 and bone metastasis.