MKI67 and bone metastasis: On the contrary, other potential prognostic factors such as histopathological grade (G), gender, age, primary tumor size, Ki-67, cardiac surgery, stable disease due to somatostatin analogues use, peptide-receptor radionuclide therapy, coexistence of tricuspid regurgitation with pulmonary regurgitation and presence of bone metastasis were not significantly related to the OS in patients with CHD (Figure 3).