In a multinational, randomized, crossover trial (Fuzzy Logic Automated Insulin Regulation [FLAIR]), patients aged 14–29 years old showed improved glycemic control without increasing hypoglycemia, i.e., mean difference of time with glucose levels below 54 mg/dL (<3.0 mmol/L) (advanced hybrid closed-loop system minus 670G system) −0.06% (95% CI −0.11 to −0.02); p < 0.0001 for non-inferiority) [94]. This evidence concerns the gene INS and Hypoglycemia.