OTOF and deafness: Genetic auditory synaptopathies generally only cause deafness, such as the mutations in the CACNA1D gene encoding the Cav1.3L-type Ca2+ channel, the OTOF gene encoding Otoferlin, the SLC17A8 gene encoding Vglut3, or the DIAPH3 gene encoding the diaphanous formin 3.