Autosomal-dominant optic atrophy (DOA) is the most frequent form of hereditary optic neuropathy [66], with a reported frequency of 1:10,000, and is caused by heterozygous variants in the OPA1 gene encoding a mitochondrial-dynamin-related large GTPase [67,68,69]. Here, OPA1 is linked to autosomal dominant optic atrophy.