Subcutaneous administration of the NT-3 peptide in nude mice harboring CMT1A xenografts, TremblerJ mice with a peripheral myelin protein 22-point mutation, and CMT1A patients resulted in improved axonal regeneration in animal models for CMT1A and provided beneficial effects in patients [119]. The gene discussed is PMP22; the disease is Charcot-Marie-Tooth disease type 1A.