CASP3 and cervical cancer: Supporting our results, previous studies have shown that AM induces apoptotic cell death by increasing Bax and cytochrome c release, decreasing Bcl-2, and activating caspase-9/caspase-3 cascade as well as the ASKI/MKK3/6/p38 signaling pathway in HeLa and SiHa cervical cancer cells [26].