Through GSE dataset analysis and in vitro experiments, another controlling network with circ_0001955/ miR-516a-5p/ TRAF6 and MAPK11 axis, it has also been reported that circ_0001955 can facilitate HCC tumor growth by sponging miR-516a-5p to boost TRAF6 and MAPK11 expression [79]. This evidence concerns the gene TRAF6 and hepatocellular carcinoma.