Interestingly, some of the common down-regulated genes, such as EPHA7 and NSUN7, are known for both their tumor suppressing and promoting roles, or are associated with overall survival (OS) (SLC22A31) [29,30,31,32], while others have clear pro-tumorigenic roles (ADGRF1, LOX, LY6G5C, SNAI2, TNFRSF11B, ZNF233) [30,33,34,35,36]. The gene discussed is LY6G5C; the disease is neoplasm.