Among them, several up-regulated genes are known to be involved in the formation of tumor microenvironments (Carbonic anhydrase 2 (CA2)) [24,25], cancer chemoresistance (Cannabinoid receptor 1 (CNR1) [26], GFRA1 [27]) and cancer recurrence after therapy (RGL3) [27,28]. The gene discussed is CA2; the disease is neoplasm.