Previously reported positive correlation between radioresistance of human HNSCC cell senescence accompanied by NF-κB-dependent production of distinct senescence-associated cytokines [16], together with the up-regulation of NF-κB signaling observed in our study, allowed us to assume their potent role in NSCLC radioresistance. The gene discussed is NFKB1; the disease is head and neck squamous cell carcinoma.