In this additional cohort of 139 patients with endometrioid EC, there was no significant difference in overall survival between patients, with a higher percentage of ERα-positive cells versus patients with a lower percentage of ERα-positive cells, but there was a trend of better survival in EC with high ERα levels (above the cutoff value of 80% of positive tumor cells) (Supplementary Figures S8 and S9). The gene discussed is ESR1; the disease is neoplasm.