A statistical analysis revealed that PDIA3 expression was significantly reduced in the amygdala (−55%, p < 0.01, Figure 1A), entorhinal cortex (−41%, p < 0.001, Figure 1B), and ventral hippocampus (−46%, p < 0.01, Figure 1D) of 6-month-old 3×Tg-AD mice; surprisingly no significant effect was observed in the dorsal hippocampus (Figure 1C). The gene discussed is PDIA3; the disease is Alzheimer disease.