PDIA3 and Alzheimer disease: Interestingly, 18-month-old 3×Tg-AD mice showed a significant increase of PDIA3 levels in the amygdala (+130%, p < 0.01, Figure 1A) and entorhinal cortex (+38%, p < 0.05, Figure 1B), while only a trend toward an increase was observed in the ventral hippocampus (+31%, n.s., Figure 1D), as compared to 6-month-old 3×Tg-AD mice; surprisingly, a significant decrease was observed in the dorsal hippocampus (−34%, p < 0.001, Figure 1C).