GFAP and Alzheimer disease: Previous studies have reported that PDIA3 transcript is abundantly expressed in all cerebral cell types [47], therefore we profiled the pattern of PDIA3 expression in both NeuN-positive differentiated neurons and GFAP-positive astrocytes of 6- and 18-month-old 3×Tg-AD mice, referred to as the mild and severe AD-pathology groups, respectively.