In line with the latter observation, it has been reported that diosgenin, a plant-derived steroidal saponin structurally similar to calcitriol, an endogenous PDIA3 ligand, acts as an exogenous activator of PDIA3, improving memory performance in the object recognition test by reducing amyloid plaques and neurofibrillary tangles in the cerebral cortex and hippocampus of 5XFAD mice, an engineered mouse model of AD harboring five familial AD mutations [36]. The gene discussed is PDIA3; the disease is Alzheimer disease.