Given the known potential roles of PDIA3 in aging, as well as in neurodegenerative diseases, we longitudinally analyzed the changes of PDIA3 protein levels in some limbic brain regions of Non-Tg and 3×Tg-AD mice, which develop both Aβ and tau pathologies in an age-dependent manner. The gene discussed is MAPT; the disease is neurodegenerative disease.