Moreover, by analyzing the expression pattern of PDIA3 in 6- and 18-month-old 3×Tg-AD mice, we observed, for the first time, the expression of PDIA3 in differentiated neurons and astrocytes from the basolateral amygdala, entorhinal cortex, and dorsal and ventral CA1 regions of the hippocampus. This evidence concerns the gene PDIA3 and Alzheimer disease.