Although these data are limited, in aggregate they suggest that the various forms of AM all share the characteristic of activating both virus-associated (TLR3, TLR7, TLR8 or TLR9) and bacteria-associated (TLR2 and TLR4) innate receptors with severe COVID-19, KD and MIS-C. The gene discussed is TLR4; the disease is COVID-19.