Severe COVID-19 differs radically from asymptomatic and mild cases in many ways, including presentation with an atypical cytokine storm characterized by lymphopenia, neutrophilia and an increased neutrophil-to-lymphocyte and neutrophil-to-CD8+ T cell ratio; increases in concentrations of inflammatory cytokines produced from both the TRIF and MyD88 pathways, including IL-6, TNF-α, IL-1β, IL-8, IL-10, and IL-18; and production of neutrophil extracellular traps [13,14,15]. Here, MYD88 is linked to COVID-19.