Here, it is important to reiterate the point that while individual autoantibodies do not predict the incidence of COVID-19 coagulopathies and combinations of anti-CL and anti-β2GPI antibodies, as well as, in some cases, antibodies against additional blood proteins such as collagens, von Willebrand Factor and prothrombin [70,84,85,216,217,218,219], do. This evidence concerns the gene VWF and blood coagulation disease.