NLRP3 and COVID-19–associated multisystem inflammatory syndrome in children: MIS-C patients have been reported to have up-regulated TLR2 [56,128], TLR3 [129,130,131], TLR4 [130], TLR6 [131], TLR7 [56,129,132], TLR8 [56], NLRP3 [57], RIG-1 [128] and MDA-5 [128].