Because LPS would not be involved in the pathogenesis of MIS-C, [emphasis added] molecular patterns other than those from Gram-negative bacteria must be involved in the induction of non-canonical inflammasome in MIS-C.” In fact, as noted above, the presence of unusually large amounts of LPS and other bacterial antigens have been documented in severe COVID-19 patients with NLRP3 inflammasome activation [19,20,21,22,23,24,197,198,199], and specifically in MIS-C patients [211], so that LPS activation of the non-canonical inflammasome is actually very likely. Here, NLRP3 is linked to COVID-19–associated multisystem inflammatory syndrome in children.