TNF and COVID-19: However, MIS-C does share many clinical commonalities with severe COVID-19, including the presence of co-infections with Streptococcal and Staphylococcal bacteria [39,40,41,48], presence of coagulopathies, increases in C-reactive protein (CRP), ferritin, procalcitonin, D-dimer and fibrinogen, an increased prothrombin time and over-production of IL-2, IL-6, IL-8 and TNFalpha [38,39,40,41,48,49,50].