However, the previous section also demonstrates that SARS-CoV-2 is very unlikely to able to account for this broad stimulation pattern or the consequent cytokine over-production syndrome that characterizes severe COVID-19 and its autoimmune complications because it activates only a few of the virus-associated (endosomal and intracellular) innate receptors (TLR3, TLR7, NLRP3 and RIG-1). This evidence concerns the gene NLRP3 and COVID-19.