RIGI and COVID-19: However, the previous section also demonstrates that SARS-CoV-2 is very unlikely to able to account for this broad stimulation pattern or the consequent cytokine over-production syndrome that characterizes severe COVID-19 and its autoimmune complications because it activates only a few of the virus-associated (endosomal and intracellular) innate receptors (TLR3, TLR7, NLRP3 and RIG-1).