In the same context, low methylation levels of cg11538848 and cg20948051 and high methylation levels of cg23675362, cg18440470, and cg22026687 have been linked to an unfavorable prognosis, thereby highlighting XPR1 as a potential biomarker with a dual diagnostic and prognostic role in HNSCC [33]. Here, XPR1 is linked to head and neck squamous cell carcinoma.