Furthermore, the receptor-like PTP type T (PTPRT) seems to be frequently hypermethylated in HNSCC; being a negative regulator of STAT3, PTPRT hypermethylation and subsequent reduction in PTPRT expression levels induce an increase in STAT3 activation and thereby sensitivity to STAT3 inhibition [80]. Here, PTPRT is linked to head and neck squamous cell carcinoma.