The EDNRB gene encodes the B-type endothelin receptor (G protein-coupled receptor) that activates a phosphatidylinositol-calcium second messenger system, while DCC, a tumor suppressor gene, encodes a transmembrane protein with structural homology to NCAM, which is involved in the differentiation of epithelial and neuronal cells [22]. This evidence concerns the gene EDNRB and neoplasm.