SSTR1 hypermethylation has been detected in 64% of HNSCC samples and has also been associated with tumor extent, disease stage, SST hypermethylation, and increased expression of galanin (GAL), GALR2, TAC1, and tachykinin type 1 receptor (TACR1) [35]. This evidence concerns the gene GALR2 and head and neck squamous cell carcinoma.