A study on the nuclear factor I (NFI) family of transcription factors (namely NFIA, NFIB, NFIC, and NFIX) in various cancers, including HNSCC, has revealed significantly reduced expression levels in all NFI family members in HNSCC patients, as compared to controls, and a negative correlation with DNA methylation; accordingly, decreased expression levels of NFIA, NFIB, and NFIC have been correlated with shorter OS [46]. This evidence concerns the gene NFIB and cancer.