In addition, control mice with 2 cycles of 5-FU injection displayed an excessive increase in the spleen index (Figure 6H) but a decrease in the proportions of CD19+ B cells and CD3+ T cells in the spleen (Figure 6I,J), which were, however, all relieved to some extent by BC pretreatment (Figure 6H–J). The gene discussed is CD19; the disease is breast cancer.