More specifically, the nuclear hormone receptors NR2E3 and RORA (Retinoic-acid-receptor-related orphan receptor alpha), as members of the ligand-dependent steroid hormone receptors that function as transcription factors, regulate the generation of cone and rod cells and have relevant implications in AMD pathogenesis, with confirmed directed binding to miRNA-containing loci [102,103,104,105,106]. The gene discussed is RORA; the disease is age-related macular degeneration.