For CRC treatments, Fluoropyrimidine (5-Flourouracil, 5-FU) is the gold standard of first-line treatment: 5-FU acts through the inhibition of cellular thymidylate synthase (TS) and leads to a thymine-less cell death, though 5-FU resistance can be developed and is commonly observed [5]. Here, TYMS is linked to colorectal carcinoma.