MSTN and Cirrhosis: Tsien et al. reported increased myostatin expression in patients with cirrhosis [32], in accordance with data previously obtained by García et al., who found a fourfold increase in serum myostatin in 36 patients with cirrhosis compared with 6 controls [33] and also with the results of an experimental study in which myostatin seemed to activate several pathways involved in liver fibrous tissue deposition [34].