A recent study showed that abrogating the expression of lysosomal glutamine and asparagine transporter SNAT7 regulates mTORC1-dependent macropinocytosis and pancreatic cancer cell proliferation, suggesting nutrients uptake through macropinocytosis is critical for SNAT7-mTORC1 signaling [36]. This evidence concerns the gene SLC38A7 and familial pancreatic carcinoma.