Any defects in phagocytosis results in impaired apoptosis machinery and results in a defective immune response and may cause susceptibility to various diseases including autoimmunity, chronic granulomatous disease, myeloperoxidase (MPO) deficiency, Chediak–Higashi syndrome, lazy leukocyte syndrome, leukocyte adhesion deficiency, Job’s syndrome, and chemotactic disorders [28]. This evidence concerns the gene MPO and periodic fever, immunodeficiency, and thrombocytopenia syndrome.