Since CD62E is synthesized after activation by inflammatory stimuli [34,35], the higher values of CD62E+ EVs in BAL of COPD patients with respect to both smokers without COPD and nonsmokers could express significant inflammatory damage of pulmonary vascular endothelium, pathologically related to COPD itself, and not completely explained by the smoking history. Here, SELE is linked to chronic obstructive pulmonary disease.