In fact, at variance with kinase-driven leukemias such as chronic myeloid leukemia (CML) and Philadelphia-positive B-cell precursor acute lymphoblastic leukemia (B-ALL), T-ALL causes the aberrant expression of genes encoding transcription factors (e.g., TAL1, TAL2, LYL1, BHLHBL1, LMO, LMO2, TLX1/HOX11, HOX11L2, HOXA, etc., reviewed in [8]) which are notoriously very difficult to target [187]. This evidence concerns the gene LYL1 and chronic myelogenous leukemia, BCR-ABL1 positive.