CD8A and acute lymphoblastic leukemia: ETP-ALL (characterized by a very immature CD4− CD8− DN phenotype and the expression of both stem cell and myeloid-associated markers [183], commonly display mutations in transcription factors associated to hematopoietic and T-cell development (GATA3, ETV6, RUNX1), to epigenetic regulators (DNMT3A, IDH1, IDH2, EZH2,), and signaling pathways, including FLT3 and NRAS [184].