AKT1 and cancer: Following this criterion, it was demonstrated that quercetin treatment decreases AKT phosphorylation, leading to reduced activity of downstream target proteins, including glycogen synthase kinase 3 alpha/beta (GSK3α/β) and WNK lysine deficient protein kinase 1 (WNK-1), a protein that in other cancer types is linked to epithelial–mesenchymal transition (EMT) promotion.