The interaction of quercetin with CB1-R with consequent anti-proliferative effects was also investigated in vivo using CRC-induced mouse model, in which mice were fed with 0.5% quercetin during CRC induction and, also in this case, increase in CB1-R protein level was observed in normal mice and even more strongly it was observed in quercetin-treated CRC-induced mice [106]. The gene discussed is CNR1; the disease is colorectal carcinoma.