IRF6 and neoplasm: Cui Y. et al. [102] performed high-precision scRNA-Seq on pituitary neuroendocrine tumors (PitNETs) and identified three normal endocrine cell types by unsupervised clustering (PIT-1, T-PIT, and SF-1, the most specific markers for tumor classification), and the differential gene SOX9 is highly expressed in tumors expressing T-PIT and SF-1, leading to PitNETs.