The scRNA-Seq results showed six clusters of B cells in NSCLC, namely naive B cells with TLR10 and FCRL1, plasma-like B cells with high levels of AP2A1 and AP2M1 expression, CD20−CD19−CD79A+CD79B+ B cells with high levels of AP2A1 and AP2M1 expression, CD20−CD19−CD79A+CD79B+ B cells, CD20+ B cells in NSCLC, TRIM21-mediated immunoglobulins B cells, and targeting immunoglobin (IgG) B cells. The gene discussed is AP2M1; the disease is non-small cell lung carcinoma.