Inhibition of iOPN expression mediated by Type-I IFN receptor (IFNAR) expressed by DCs de-repressed interleukin-27 (IL-27) secretion, and as a result, prevented Th17 responses in vitro and in vivo, which, when aberrantly expressed, has been associated to the generation of autoimmune diseases [25]. Here, IL27 is linked to autoimmune disease.