The AR regulates the transcription of several lipogenic and cholesterogenic enzymes overexpressed in PCa, such as ATP-citrate lyase, acetyl-CoA carboxylase, FA synthase (FASN), stearoyl-CoA desaturase-1, 3-hydroxy-3-methylglutaryl-CoA reductase, and squalene epoxidase [111], with the transcription factors called sterol regulatory element-binding proteins (SREBPs) as a mediator in this process [112]. Here, HMGCR is linked to posterior cortical atrophy.