MYD88 and obesity due to melanocortin 4 receptor deficiency: Again, isoflavones, such as formononetin and ononin may turn out to be good candidates in obesity management, considering their potent anti-inflammatory effect on the LPS-stressed zebrafish models, via reducing the expression of proinflammatory cytokines and targeting myeloid differentiation primary response 88 (MyD88) or TIR-domain-containing adapter-inducing interferon-β (TRIF) ERK/JNK pathways [92].