AGER and cardiovascular disorder: Other polymorphisms, such as the A allele of the 374 T/A polymorphism, are linked to a lower risk of cardiovascular disease [25], whereas Gly allele of Gly82Ser, G allele of 2184 A/G, and C allele of the 429 T/C polymorphism are associated with increased sRAGE concentrations and RAGE expression [26,27,28,29,30].