These include regulation of EV trafficking of anti- and pro-oncogenic miRNAs in temozolomide-treated glioblastoma [56]; induction of ERK and JNK kinase pathways, which promotes autophagy in vincristine- and doxorubicin-treated canine neoplastic cells [103]; GRP55 inhibition, which reduces growth and cell cycle progression in gemcitabine-treated PDAC cells [36]; and ROS induction in oxaliplatin-treated colorectal cell lines [76]. This evidence concerns the gene MAPK8 and glioblastoma.