The contribution of splice variants to EMT has been described in lung cancer (reviewed in [22]) but has not yet been explored in PM, although we have observed [11] an inverse relationship between RNA editing at splice sites and the alternative splicing in Filamin B (FLNB), which was shown to be associated with the epithelial to mesenchymal phenotype in breast cancer [23]. The gene discussed is FLNB; the disease is breast carcinoma.