Splice variants have been identified in mesothelioma with mutated SF3B1 splicing factor [3], but have not yet been systematically analyzed, although we have documented their occurrence in several mesothelioma-relevant genes such as lncRNA GAS5, CALB2 and RBM8A [17,18,19], or in major mesothelioma tumor suppressors such as NF2 [20] and BAP1 [21]. This evidence concerns the gene CALB2 and neoplasm.