CDH1 and benign prostatic hyperplasia: Alonso detected 16 BPH samples and found that: (I) areas where prostatic epithelial cells did not express E-cadherin had lost polarization and became spindle-shaped (nuclei of these cells are strongly positive for pSmad 3 and Snail); and (II) areas where the walls of the blood vessels were extremely thick lost the endothelial layer, which was considered characteristic of EMT [4].