IFNGR1 and infection: Similar to the aerosol infection results, we saw no difference between Gbpchr3−/− and wild type animals, while IFNγR−/− animals had 10 times more Mtb growth in the spleen Figure 3E. Thus, unlike the loss of IFNγR, the loss of chromosome 3 GBPs does not affect Mtb growth in the lungs or spleen, regardless of infection route, suggesting no major function of these five GBPs in controlling antimicrobial resistance to Mtb in mice.