In addition, EPS which were isolated from L. plantarum YW11 reduced the production of the proinflammatory cytokines (TNFα, IL-1β, IL-6, IFN-γ, IL-12 and IL-18) and up-regulated IL-10, and this resulted in an amelioration of inflammatory bowel disease symptoms [48]. This evidence concerns the gene IL10 and inflammatory bowel disease.