The UDP-GlcNAc pyrophosphorylase-1 like 1 (UAP1L1) is another upstream driver of CDK6 in gastric cancer, as the phenotypes observed in UAP1L1 overexpressing cells were reversed in CDK6-silenced cells, suggesting that gastric cancer progression depends on CDK6 activity via multiple pathways [128]. The gene discussed is CDK6; the disease is gastric cancer.