One of the biomarkers of gastric cancer, known as Annexin A4, which functions as an intracellular Ca2+ in gastric cancer cells, has been shown to be one of the upstream factors for upregulating the CDK1 mRNA along with other factors such as hyaluronan-mediated motility receptor (RHAMM) and an inhibitor of p21. This evidence concerns the gene HMMR and gastric cancer.