CDKN1A and gastric cancer: Luteolin is another flavonoid that has been investigated for cellular phenotypes in gastric cancer cells, and it also reduced the protein levels of CDC25C, Cyclin B1, and CDK1, and increased the levels of CDK inhibitor p21 with the induction of apoptosis indicated by levels of p53, Caspase 3, 6, 9, and Bax [203].