Since post-transduction alterations such as increased phosphorylation and cleavage of the TDP-43 protein have been found in 97% of ALS patients [20], we then evaluated the effects of R573G TBK1 mutation on the levels and phosphorylation status of TDP-43 in control and E7 derived lymphoblasts. The gene discussed is TBK1; the disease is amyotrophic lateral sclerosis.