Collectively, the results of this study suggest that IL-1α, but not IL-1β, is responsible for IL-1R1-dependent neonatal murine sepsis lethality, and that pharmacological inhibition of IL-1α has little therapeutic value, likely due to the difficulty of neutralizing the local production and paracrine action of IL-1α with a systemic treatment [285]. Here, IL1B is linked to Sepsis.