Notably, WT pups had a simplified distal lung architecture and larger saccular structures, and NLRP-3 knockout (KO) pups had a normal lung architecture and well-formed alveoli, highlighting the importance of the NLRP-3 inflammasome and IL-1-mediated inflammation in the pathophysiology of BPD [161]. Here, IL1A is linked to bronchopulmonary dysplasia.