A study using HCC cell lines and xenograft models has reported that microrchidia 2 (MORC), which forms a complex with DNMT3A on the promoters of neurofibromatosis type 2 (NF2) and kidney and brain protein (KIBRA) that cause DNA hypermethylation and transcriptional repression, is associated with HCC resistance to sorafenib and maintenance of oncogenic potential [164]. The gene discussed is MORC1; the disease is hepatocellular carcinoma.