Furthermore, protein arginine N-methyltransferase 6 has been shown to methylate arginine 100 at CRAF and inhibit the former extracellular matrix complex subunit/RAF binding ability, thereby altering the ERK-mediated nuclear transport of pyruvate kinase M2 isoform (PKM2) and reducing sorafenib resistance in HCC cells [166]. The gene discussed is PKM; the disease is hepatocellular carcinoma.