AKT1 and hepatocellular carcinoma: In addition, the molecular mechanisms that promote VM in HCC include the regulation of lysyl oxidase homolog 2 via HIF-1α expression [107], increased translation of yes-associated protein by methyltransferase 3, an m6A methyltransferase [108], activation of the PI3K/Akt/matrix metallopeptidase pathway [109], induction of the EMT pathway by neurogenic locus notch homolog protein 1 [110] and heat shock protein 90 beta (Hsp90β) [111], and induction of VM formation by bone morphogenetic protein 4 [112] and migration-inducing gene 7 [113].