An experiment using sorafenib-resistant HCC cells has revealed that miR-374b binds to the 3′-UTR of hnRNPA1 and downregulates its expression, resulting in reduced PKM2 levels, suggesting that the miR-374b/hnRNPA1/PKM2 axis is an important mechanism in acquiring sorafenib resistance in HCC cells. The gene discussed is PKM; the disease is hepatocellular carcinoma.