IL4 and neoplasm: The classification of macrophages by activation state divides them into two subtypes: M1, tumor suppressor macrophages that undergo classical activation by interferon alpha (IFN-α), IFN-β, and IFN-γ, an indicator of the Th1 response, and M2, tumor-promoting macrophages that are activated by anti-inflammatory factors such as Th2, IL-4, and IL-10 [96].