Another study showed that melatonin promotes FOXA2 expression and upregulates lncRNA Carbamoyl-phosphate synthetase 1 during the downregulation of hypoxia-induced factor-1α (HIF-1α), inhibiting EMT and HCC carcinogenesis [74], which may be a therapeutic strategy to target IncRNA. Here, HIF1A is linked to hepatocellular carcinoma.