In a study investigating the role of the lncRNA nuclear-enriched abundant transcript 1 (NEAT1) in regulating HCC sensitivity to sorafenib, miR-335 has been found to increase sorafenib sensitivity via apoptosis induction and reduce tumor size in xenograft mouse models implanted with HCC cells following the knockdown of the NEAT1 gene [171]. This evidence concerns the gene NEAT1 and hepatocellular carcinoma.