Several studies on other miRNAs have shown that the aberrant expression of miR-19a-3p induces sorafenib resistance in HCC cells by regulating the PTEN/Akt pathway [86], and that the overexpression of miR-494 enhances sorafenib resistance against HCC cells via the activation of the mTOR pathway [176]. Here, AKT1 is linked to hepatocellular carcinoma.