INS and hepatocellular carcinoma: In another report on histone H3 acetylation it was shown that insulin induced major transcriptional factors such as sterol regulatory element-binding transcription factor 1c (SREBP-1c) and carbohydrate responsive element-binding protein (ChREBP) binding with sterol regulatory elements (SRE) or carbohydrate-responsive elements (ChORE) of the fatty acids synthase (FASN) promoter and induces FASN expression in normal tissue, while the hyperacetylation of histone H3 and H4 impaired SREBP-1c-SRE and ChREBP-ChORE binding on the FASN promoter and HCC became insulin resistant [46].