Interestingly, another study has shown that COP9-signaling corset 5 (CSN5) is associated with sorafenib resistance in HCC cells, and that silencing CSN5 expression abrogates resistance to sorafenib and downregulates ABCB1, ABCC2, and ABCG2 [184]. Here, COPS5 is linked to hepatocellular carcinoma.