EMT appears to be a central mechanism in the emergence of regorafenib resistance to HCC, and regorafenib-resistant HCC cells overexpress peptidyl-prolyl cis-trans isomerase 1 (Pin1), which regulates the expression of EMT-related molecules such as E-cadherin and promotes HCC progression, invasion, and metastasis [197]. This evidence concerns the gene PIN1 and hepatocellular carcinoma.