Several miRNAs have been shown to be altered in lenvatinib-resistant HCC, and the downregulation of miR-128-3p displays the strongest activity in negatively regulating c-Met, as it is involved in the resistance mechanism via AKT, which regulates the apoptotic pathway, and ERK, which regulates the cell cycle [213]. The gene discussed is AKT1; the disease is hepatocellular carcinoma.