CYP24A1 and glaucoma: In conclusion, we synthetized and investigated a novel griseofulvin and usnic acid sulfonamides for their effective inhibition against three relevant human carbonic anhydrase isoforms, such as the ubiquitous hCA I and hCA II isoforms and the tumor-associated isoforms hCA IX, which are involved in many diseases such as glaucoma, retinitis pigmentosa, epilepsy, and tumors.