Interestingly, this was accompanied by a significant elevation in the levels of both pY1068-EGFR (p = 0.03) and pS473-Akt (p = 0.003) in the FaDu cells, suggesting a molecular-feedback mechanism in this cell line, which has been described previously in pancreatic- and colon-cancer cells [13,22]. Here, AKT1 is linked to malignant colon neoplasm.