TOM1L2 shows considerable overlap in amino acid sequence with TOM1 (59%) and TOM1L1 (30%) [36] In vitro a fragment of the TOM1L2 GAT domain binds TOLLIP [37] This is of specific interest, as the minor alleles of the common SNPs rs111521887 and rs5743894 in the TOLLIP gene are associated with IPF. Here, TOM1L1 is linked to idiopathic pulmonary fibrosis.