TOM1L2 shows considerable overlap in amino acid sequence with TOM1 (59%) and TOM1L1 (30%) [36] In vitro a fragment of the TOM1L2 GAT domain binds TOLLIP [37] This is of specific interest, as the minor alleles of the common SNPs rs111521887 and rs5743894 in the TOLLIP gene are associated with IPF. The gene discussed is TOM1; the disease is idiopathic pulmonary fibrosis.