The 5p15.33 region encompassing the TERT-CLPTM1L genes has been associated with the risks of at least 11 different cancers, including lung, prostate, breast, pancreatic, bladder, esophageal, endometrial, gastric, and head and neck cancers, glioma, and melanoma [28,32,41,42,43,44,45,46]. The gene discussed is CLPTM1L; the disease is head and neck cancer.