TRPS1 and cancer: Recent studies have suggested that TRPS1 is overexpressed in several cancers and can act as an oncogenic driver through various mechanisms [53], such as driving heterochromatic origin refiring and genome amplifications [54], controlling the cell-cycle progression [55], promoting epithelial-to-mesenchymal transition [56], promoting angiogenesis [57], and causing epigenetic alterations (DNA methylation and histone acetylation) [50,58,59].