Specifically, for oral cancer, previous GWAS identified three loci in the HLA region, including rs3828805 (chromosome 6 position 32636120) [27] and rs3135001 (6:32670136) in HLA-DQB1 (6p21.32) [28] and rs1265081 (6:31111675) in CCHCR1 (6p21.33) [28]. The gene discussed is HLA-DQB1; the disease is lip and oral cavity carcinoma.