Our findings here suggested that the covert increase in the rate of bone turnover may have predisposed individuals to the occurrence of DJD-TMJ, despite no symptomatic signs of osteoporosis, including estrogen deficiency or other bone/cartilage degenerative diseases being observed, and that the higher tendency of CCL5 level in the DJD-TMJ was likely to be associated with a degenerative condition of temporomandibular joints. The gene discussed is CCL5; the disease is osteoporosis.