Representative histology images of tumors stained for myc-tag, γ-H2AX, ki67, and H&E as well as tumor size (Figure 3D) show that BRG1-BRD overexpression in oNIS-expressing cells suppresses cancer cell proliferation and increases DNA DSBs, which enhances the effect of I-131 radiotherapy. This evidence concerns the gene SMARCA4 and cancer.