Histological analysis of tumor sections showed that DNA DSBs, as represented by the γ-H2AX marker, increased 1.4-fold (2.22 MBq) and 1.3-fold (18.5 MBq) in the oNIS+BRD group and the oNIS alone group, respectively, after I-131 treatment (p < 0.005) (Figure 3E). The gene discussed is H2AX; the disease is neoplasm.