These observations were in line with histological analyses of tumors, where statistically significant reductions in vasculature (to 38.7%) and proliferating tumor cells (to 64.4%) were observed, while levels of hypoxia, apoptosis, necrosis and granzyme B-positive cells were statistically significantly elevated compared with the control group and monotherapies. The gene discussed is GZMB; the disease is neoplasm.