HMGB1 and cancer: We have previously shown that HMGB1 increases the expression of oncogenic miR-221 and miR-222 in CAL-62 cells and BCPAP cells and in the present study, we show for the first time that HMGB1 is packed into exosomal vesicles and secreted in vitro by the anaplastic cell line CAL-62, probably in order to preserve its semi-oxidized status, which functions as a cytokine that induces angiogenesis and factors related to cancer progression and survival in hypoxic conditions [34].