We looked for common genes between the up-DPpGCs in TS and TA, and the significant differentially expressed genes (DEGs) induced by exercise in SkM of old mice [19], and found four genes, ATP1A3, SLC17A7, SYN2, and COL24A1 from the up-DPpGCs in TS, that are related to neurotransmission and obesity (Table S1). The gene discussed is SYN2; the disease is Obesity.