MAPT and Alzheimer disease: We found that, compared with Tg2576/UCP1+/+ mice, Tg2576/UCP1−/− mice housed at 23 °C had exacerbated AD-like pathologies due to elevated levels of Aβ, HSPs, both phosphorylated and total tau, and tau kinases, as well as enhanced glial activation and decreased synaptic protein levels.