In the brains of patients with AD and AD-like mouse models, reactive glial cells are present around Aβ plaques and play a vital role in the disease progression as they induce both Aβ deposition and the release of proinflammatory cytokines such as tumor necrosis factor (TNF-α), interleukin-6 (IL-6), and IL-1β [44]. This evidence concerns the gene TNF and Alzheimer disease.