MAPT and Alzheimer disease: We found that compared with Tg2576/UCP1+/+ mice, Tg2576/UCP1−/− mice housed at 23 °C had exacerbated AD-like pathologies due to increased Aβ, heat shock proteins (HSPs), total tau, phosphorylated tau, and phosphorylated tau kinases, as well as enhanced glial activation and decreased synaptic protein levels.