SETDB2 and lung adenocarcinoma: For example, in hepatic progenitor cells, Nrf2 induces malignant transformation due to the activation of the wnt-β-catenin pathway [135]; suppression of Nrf2 by histone lysine methyltransferase SETDB2 inhibits the progression of lung adenocarcinoma cells, whereas the decreased SETDB2 in these cells enhances Nrf2-mediated tumorigenesis [136].