MBNL1 and myotonic dystrophy type 1: The conjugation of CPPs to PMOs was shown to improve the DM1 phenotype in HSALR mice whether targeting toxic DM1 CUG repeats via a blocking mechanism for Mbnl1 displacement [35] or targeting a miR-23b binding site on the Mbnl1 3′UTR increasing Mbln1 protein levels using ASOs called blockmiRs [92].