Additional indirect evidence that unrelenting hypothalamic inflammation mediates sustained leptin resetting during obesity reversal is that the two treatments that most successfully support long-term weight loss and reverse leptin resetting also reverse hypothalamic inflammation: Roux-en-Y gastric bypass (RYGB) [192] and liraglutide [a glucagon-like-peptide 1 (GLP-1) agonist] treatment [64]. This evidence concerns the gene LEP and obesity due to melanocortin 4 receptor deficiency.