More importantly, significant DNA hypomethylation was observed in five CpG sites (CpG2, p = 0.0406; CpG3, p = 0.0159; CpG5, p = 0.0321; CpG6, p = 0.0390 and Cpg8, p = 0.0473) in PD-GBA1 samples compared to non-PD controls (Figure 1). This evidence concerns the gene GBA1 and Parkinson disease.