We analyzed the expression of known chemokines and chemokine receptors that inhibit or promote the progression of HCC [25] and found that Cluster 2 had higher expression of anti-HCC chemokines and chemokine receptors (CCL4, CCL19, CCL21, CCR5, CCR7) and lower expression of pro-HCC chemokines and chemokine receptors (CCL28 and CCR10) than Cluster 1 (Figure 3E,F). This evidence concerns the gene CCL21 and hepatocellular carcinoma.