Experimental colitis was induced by the initial topical sensitization, followed by rectal administration of TNBS (as a Th1/Th17-associated CD model [20]; Figure 1A) or oxazolone (as a Th1/Th2-associated UC model [20]; Figure 1E) in adult male WT, Cth–/–, and Mpst–/– mice. This evidence concerns the gene CTH and Cowden disease.