FOXP3 and neoplasm: Additional studies on immune response to tumors generally showed that high doses of resveratrol are cytotoxic for both cancer and beneficial effector immune cells, whereas low- and non-cytotoxic doses of resveratrol inhibit the generation and function of tumor-evoked regulatory B-cells (tBregs), including their expression of TGF-β and their ability to convert T lymphocytes into Foxp3+ Tregs, blocking tumor metastatic spreading [216].