NFKB1 and melanoma: The study also reveals that vernolide-A treatment could alter the production and expression of pro-inflammatory cytokines and inhibit the activation and nuclear translocation of p65, p50 and c-Rel subunits of NF-kB, and other transcription factors such as c-fos, activated transcription factor-2, and cyclic adenosine monophosphate response element-binding protein in B16-F10 melanoma cells [283].