Several studies demonstrated that terpinel-4-ol can affect melanoma cell proliferation/viability, overcoming the resistance to caspase-dependent apoptosis, and interfere with the migration and invasion processes of melanoma M14 cells impairing the ERM (Ezrin, Radixin and Moesin)-mediated MAPK signaling pathway [284,285,286]. This evidence concerns the gene RDX and melanoma.