In particular, Raphael and Kuttan demonstrated that administration of glycyrrhizic acid clearly enhanced the level of interleukin IL-2, the antibody-dependent cell mediated cytotoxicity (ADCC) and antibody-dependent complement-mediated cytotoxicity (ACC) in B16-F10 metastatic melanoma-bearing mice [274]. The gene discussed is IL2; the disease is metastatic melanoma.