APAF1 and melanoma: Other pumpkin-derived polyphenolic compounds such as coumaric acid show a clear anti-oxidant and anti-tyrosinase activity in mouse B16-F10 melanoma cells [207] and a relevant anti-proliferative effect down-regulating cycle-related proteins, up-regulating Apaf1 and BAX and down-regulating BCL-2, ultimately inducing apoptosis in both human and mouse melanoma cells [208].