Salicylic acid, one of the main ginseng root phenolic acid components, reduces melanin levels in mouse B16-F10 melanoma cells by inhibiting tyrosinase and tyrosinase-related proteins, as well as their master transcriptional regulator, microphthalmia-associated transcription factor (MITF) and other upstream signal regulators such as adenylyl cyclase and protein kinase A [206]. The gene discussed is TYR; the disease is melanoma.